Bring the power of Absolute Q® to your research

Digital PCR can empower a variety of applications. Find yours and see what the Absolute Q can do for you!

Interested in trying something new? We love to collaborate – contact us to discuss how the Absolute Q can make an impact on your current research efforts.

Absolute Q Digital PCR Platform Application Notes
  • All
  • Absolute Quantification
  • Gene Editing
  • Infectious Disease
  • Medium Multiplexity
  • Oncology
  • Reproductive Health
  • Wastewater Monitoring
Reproductive Health

Multiplexed Digital PCR for Non-Invasive Prenatal Trisomy Screening

In this study, we demonstrate the performance of a novel 4-color multiplexing non-invasive prenatal trisomy test on the Absolute Q dPCR platform to simultaneously detect T13, T18 and T21.

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Wastewater Monitoring

Emulsion-free Digital PCR Measurement of Wastewater Related Targets using the SARS-CoV-2 Wastewater Surveillance 4-plex Assay

Wastewater based epidemiology (WBE) enables tracking of biomarkers for specific pathogens to monitor for disease outbreak and spread. WBE’s utility in disease surveillance has been proven to be effective in monitoring for rare cases of disease.

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Infectious Disease

Testing Wastewater Samples for SARS-CoV-2 Using the Absolute Q

Screening wastewater, or sewage, for the presence of SARS-CoV-2 viral RNA can be an effective orthogonal monitoring method in addition to ongoing clinical testing. Wastewater serves as pooled samples from members of a community and enables broad collection of surveillance data.

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Infectious Disease

Using Digital PCR for Optimization of SARS-CoV-2 RNA Extraction Protocol

RNA extraction is a critical step in COVID-19 molecular testing. The loss of viral RNA during the extraction step can result in false negatives. Therefore, optimization of the RNA extraction protocol to ensure consistent and high yield recovery of viral RNA could potentially improve COVID-19 testing accuracy.

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Oncology

4-Color Discrimination of Multi-Allele Single Nucleotide Polymorphisms on the Absolute Q

In this application note created in collaboration with Integrated DNA Technologies, we demonstrate 4-color optical multiplexing for multi-allele single nucleotide polymorphism discrimination.

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Gene Editing

Evaluation of CRISPR-Cas9 Mediated Genome Edits with the Absolute Q Digital PCR platform

CRISPR-Cas 9 technology has been rapidly adopted due to its ability to make precise edits in the genome. Here, we demonstrate using the Absolute Q to accurately identify both knock-ins and knock-outs.

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Infectious Disease

Testing qPCR positive, negative and inconclusive COVID-19 clinical samples using digital PCR

In this study we tested nucleic acids extracted from 19 clinical specimens using the Absolute Q to demonstrate the improved sensitivity and accuracy of RT-dPCR over traditional RT-qPCR.

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Infectious Disease

|Q| SARS-CoV-2 Triplex Assay: Multiplexed 1-step RT-dPCR for Accurate Viral Target Detection

Leveraging the Absolute Q’s qPCR-like workflow, we showcase the multiplexed 1-step |Q| SARS-CoV-2 RT-dPCR assay by quantifying viral target input with high accuracy down to 5 copies per reaction.

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Oncology

Precise BCR-ABL1 Quantification for Chronic Myeloid Leukemia (CML) Monitoring

Monitoring of the BCR-ABL1 fusion gene is integral to successful TKI treatment in Chronic Myeloid Leukemia. See how the Absolute Q provides accurate measurement of the BCR-ABL1/ABL1 ratio.

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Reproductive Health

4-color Copy Number Variation (CNV) Assay for Spinal Muscular Atrophy (SMA) Screening

Spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality. Here, we describe a 4-plex digital PCR assay capable of quantifying the copy numbers of SMN1 and SMN2 genes, which are central to SMA.

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