Combinati Blog

As dPCR is a relatively new approach to nucleic acid detection and quantification, this blog is designed to be a resource for both new and experienced dPCR users.
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Planning and preparing a digital PCR experiment

Digital PCR (dPCR) is a polymerase chain reaction (PCR) method that enables the absolute quantification of nucleic acids. This post describes how to prepare for a digital PCR reaction and provides tips to achieve optimal results.

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What is Copy Number Variation and how can I use digital PCR to measure CNV?

Absolute quantification can be extremely useful for measuring copy number variation. Digital PCR, which utilizes simple counting of target molecules to achieve absolute quantification, enables higher precision and accuracy to detect and quantify copy number variations – even if the changes are minor.

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What is the difference between quantitative PCR and digital PCR?

Quantitative PCR (qPCR) and digital PCR (dPCR) are both methods of determining the quantity of a particular nucleic acid target in a given reaction. To …

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Routine wastewater monitoring: why is digital PCR the best approach?

Routine wastewater monitoring is a more cost-effective way to monitor transmission dynamics because sewage influent effectively pools samples from an entire community.

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Improving Consistency in Wastewater Testing

Wastewater based epidemiology, or WBE, is a method of testing wastewater for the genetic material of pathogens which can be used as a biomarker for …

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Using Wastewater Based Epidemiology to Fight COVID-19

As of December 2020, COVID-19 has infected over 72 million people globally, causing over 1.6 million deaths, with numbers expected to rise through the early …

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