Technical notes, application notes and protocols that feature Combinati technology across various research areas, key applications, and assay scale.
- All
- Infectious Disease
- Oncology
- Reproductive Health
- All
- Infectious Disease
- Oncology
- Reproductive Health
Experiment Flexibility with the Combinati™ Absolute Q Digital PCR Platform
Microfluidic Array Partitioning (MAP) technology utilizes fixed microchamber arrays and positive pneumatic pressure to partition reagents and perform digital PCR, instead of using fluid-shearing to generate droplets.
SARS-CoV-2 Reference Material Quantification on the Absolute Q dPCR Platform
To address the need for a reliable method of accurate and precise measurements of SARS-CoV-2 samples, we leverage the Combinati Absolute Q Digital PCR (dPCR) platform, to quantify commercially available SARS-CoV-2 reference control material.
IDT rhAmp EGFR p.T790M Genotyping on the Combinati Absolute Q
Integrated DNA Technologies’ rhAmp SNP Genotyping System enables highly precise interrogation of SNPs within difficult genomic regions. For the first time, the IDT rhAmp assay performance was demonstrated on a digital PCR platform — quantifying EGFR p.T790M mutation down to 0.1%.
BCR/ABL Gene Expression Assay on the Combinati Absolute Q
95% of Chronic Myeloid Leukemia (CML) cases are characterized by the presence of a BCR-ABL1 fusion gene. Regular monitoring involving precise quantification of BCR-ABL1 transcripts is integral to successful tyrosine kinase inhibitor (TKI) treatment. Read more about how samples with precise ratios of BCR-ABL1/ABL1 were created and confirmed on the Combinati dPCR platform.
Quadruplex Absolute Q Digital PCR for Spinal Muscular Atrophy (SMA) Screening
Spinal muscular atrophy (SMA), a genetic neuromuscular disorder and leading genetic cause of infant mortality. Here we describe a 4-color multiplexing digital PCR solution on the Combinati Absolute Q to meet the growing demand for rapid SMA newborn screening and treatment.
TaqMan™ Liquid Biopsy assays for rare target quantification
Digital PCR (dPCR) enables rare target detection even in the presence of high non-target background. Read more about how the Applied Biosystems™ TaqMan™ Liquid Biopsy dPCR Assays were used to perform rare target detection for 5 hot-spot cancer mutations on the Combinati Absolute Q platform.
