Learn how the Absolute Q® can help answer your questions

Our resources below can help you learn how a more accurate dPCR solution can advance your research.

Learn about the Absolute Q Digital PCR Platform

On Demand Learning Center

Learn from experts how digital PCR is redefining nucleic acid quantification and being leveraged to answer complex scientific questions.

Application Notes

See how the Absolute Q dPCR platform has been used for a number of applications.

Infectious Disease

Testing qPCR positive, negative and inconclusive COVID-19 clinical samples using digital PCR

In this study we tested nucleic acids extracted from 19 clinical specimens using the Absolute Q to demonstrate the improved sensitivity and accuracy of RT-dPCR over traditional RT-qPCR.

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Infectious Disease

|Q| SARS-CoV-2 Triplex Assay: Multiplexed 1-step RT-dPCR for Accurate Viral Target Detection

Leveraging the Absolute Q’s qPCR-like workflow, we showcase the multiplexed 1-step |Q| SARS-CoV-2 RT-dPCR assay by quantifying viral target input with high accuracy down to 5 copies per reaction.

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Oncology

Precise BCR-ABL1 Quantification for Chronic Myeloid Leukemia (CML) Monitoring

Monitoring of the BCR-ABL1 fusion gene is integral to successful TKI treatment in Chronic Myeloid Leukemia. See how the Absolute Q provides accurate measurement of the BCR-ABL1/ABL1 ratio.

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Posters and Publications

Combinati’s technology has been featured in posters at renowned conferences as well as published in various scientific journals.

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Technical Notes

Learn about the Absolute Q’s technical capabilities and see how microfluidic array partitioning technology can have an impact on your research efforts.

Robust Quantification of Next Generation Sequencing Libraries using Absolute Q Digital PCR

Advances in next-generation sequencing (NGS) technologies had accelerated the discovery of actionable genomic targets. Accurate quantification of the final library products is critical to maximizing both data quality and output. Multiple studies have demonstrated that utilizing digital PCR (dPCR) as a quantification tool for NGS libraries before sequencing helps optimize sequencing run performance, data generation, and data quality.

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Improve sensitivity for rare targets by increasing total analyzed sample using digital pooling of digital PCR data

For samples with very rare targets, the volume of sample input may impact the ability to detect ultra-rare events. In this technical note, the Digital Pooling feature of the Absolute Q Analysis Software is highlighted by showcasing rare target detection of mutation allele frequencies (MAF) at 0.1% using multiple MAP16 dPCR arrays.

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Using in-line process controls to evaluate sample processing workflow efficiency

An in-line process control is intended to provide quantitative information about sample loss during sample processing workflow. Typically, a process control is spiked into the initial sample before any processing takes place.

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Digital PCR Wastewater Surveillance: Detect SARS-CoV-2 alongside human fecal and process controls

In this study, we characterize the LoD of the Combinati |Q| SARS-CoV-2 RT-dPCR Triplex Kit by diluting reference materials into a pooled negative matrix to determine the lowest concentration at which the assay can reliably identify the sample as containing SARS-CoV-2 targets.

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Establishing the Limit of Detection for the |Q| SARS-CoV-2 Triplex Assay

In this study, we characterize the LoD of the Combinati |Q| SARS-CoV-2 RT-dPCR Triplex Kit by diluting reference materials into a pooled negative matrix to determine the lowest concentration at which the assay can reliably identify the sample as containing SARS-CoV-2 targets.

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1-Step Reverse Transcription Digital PCR (RT-dPCR) in Under 2 Hours

Reverse transcription allows the detection and quantification of RNA. Here, we demonstrate a true 1-step RT-dPCR workflow on the Absolute Q by quantifying SARS-CoV-2 targets in under 90 minutes.

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Customer Testimonials

What our customers have to say.